M. Crespi led a group on « Regulatory RNAs and root architecture since 2003 at the “Institut des Sciences Végétales (ISV)”, Gif sur Yvette, France. In 2015, he became Director of the new Institute of Plant Sciences from Paris-Saclay, IPS2, University of Paris-Saclay, Gif sur Yvette, France. Our laboratory is interested in deciphering the mechanisms of action of different riboregulators (regulatory non-coding RNAs) in plants. We have identified non-coding RNAs that, through their interaction with specific regulatory genes (such as splicing factors or chromatin regulators), modulate the developmental adaptation of the root system to environmental conditions.
Institute of Plant Sciences Paris Saclay IPS2, CNRS-INRA-University of Paris Saclay, 91192 Gif sur Yvette, France
Talk title and synopsis
Plant non-coding RNAs in chromatin regulation
Long non-coding RNAs (lncRNA) are major components of the eukaryotic transcriptome. We have identified lncRNAs able to modulate chromatin conformation of target loci through R-loop formation. This action was observed in cis, for neighboring loci, but also at distant loci suggesting that lncRNAs may be new elements in the three-dimensional spatial regulation of the nuclear genome